ob/ob mouse - Wikipedia
WEBThe ob/ob or obese mouse is a mutant mouse that eats excessively due to mutations in the gene responsible for the production of leptin and becomes profoundly obese. It is an animal model of type II diabetes.
000632 - B6 ob Strain Details - The Jackson Laboratory
WEBObesity is characterized by an increase in the number and size of adipocytes. Although hyperphagia contributes to the obesity, homozygotes gain excess weight and deposit excess fat even when restricted to a diet sufficient …
Novel insights into the genetically obese (ob/ob) and diabetic …
WEBJun 28, 2021 · Ob/ob mice develop an altered hepatic lipid metabolism, with a higher hepatic steatosis and inflammatory tone characterized by a marked increase in immune cell infiltration. We have explored several mechanisms that could account for this phenotype.
Novel insights into the genetically obese (ob/ob) and diabetic …
WEBJun 28, 2021 · We also found very distinct inflammatory profiles between ob/ob and db/db mice, with a more pronounced inflammatory tone in the liver for ob/ob mice as compared to a higher inflammatory tone in the (subcutaneous) adipose tissue for db/db mice.
Ob/Ob Mouse - an overview | ScienceDirect Topics
WEBThe obese diabetic mouse (ob/ob) is an excellent model for the study of obesity and diabetes as it has a longer lifespan and less severe clinical symptoms than the diabetic mouse (db/db).
The Leptin-Deficient (ob/ob) Mouse - American Diabetes …
WEBDec 1, 2006 · Here, we describe PDN in leptin-deficient (ob/ob) mice, a model of obesity and mild type 2 diabetes (17, 18) that is clearly characterized by manifest motor and sensory nerve conduction deficits, small sensory nerve fiber neuropathy, intraepidermal sensory nerve fiber loss, and oxidative-nitrosative …
The leptin-deficient (ob/ob) mouse: a new animal model of ... - PubMed
WEBThis study was aimed at characterization of PDN in leptin-deficient (ob/ob) mice, a model of type 2 diabetes with relatively mild hyperglycemia and obesity. ob/ob mice ( approximately 11 weeks old) clearly developed manifest sciatic motor nerve conduction velocity (MNCV) and hind-limb digital sensory nerve conduction velocity (SNCV) deficits ...
Ob/Ob Mouse - an overview | ScienceDirect Topics
WEB7.3.1 Obese-hyperglycemic (ob/ob) mouse. The ob/ob mice, discovered in 1949, are leptin deficient, hyperphagic, obese, hyperinsulinemic, hyperglycemic and are used as a model for diabetes and obesity [184].
Body Weight Info - Strain 000632 B6-ob - The Jackson Laboratory
WEBBody Weight Information for JAX® Mice Strain B6.Cg-Lepob/J - Stock Number 000632. Weekly weights of female and male mice between the ages of 4 and 20 weeks. Values represent the mean and one standard deviation. Cohorts began with 75 homozygous (ob/ob) and 50 heterozygous (ob/+) mice per sex.
Ob/ob mice: The Leptin Deficient Mice | Maze Engineers
WEBDec 9, 2015 · These mice are generated by targeting a point mutation to the leptin gene and are commonly referred to as the ob/ob mice (the shorthand notation “ob” was first proposed by Ingall and colleagues). Leptin is primarily found in the adipose fat tissue of normal mice. One of leptin’s key roles is help regulate appetite.