A Mouse Model of Diet-Induced Obesity and Insulin Resistance
WEBThis model has lead to many discoveries of the important signalings in obesity, such as Akt and mTOR. The chapter describes protocols for diet induced-obesity model in mice and protocols for measuring insulin resistance and sensitivity.
Use of high-fat diets to study rodent obesity as a model of …
WEBApr 9, 2019 · Mice on the 45% fat diet become obese. However, mice on the 60% fat diet become more obese, and do so more rapidly. This is advantageous because it reduces the time that the animals need to be...
High fat diet induced obesity model using four strains of mice: …
WEBMar 19, 2020 · Mouse in different strain shows much different phenotypic characteristics like growth rate, tendency of obesity, and the ability to regulate the blood glucose and lipid. So, when developing obese model using mouse, it is necessary learn how mouse in different strain response to high fat diet (HFD).
C57BL/6J substrain differences in response to high-fat diet ... - Nature
WEBAug 20, 2020 · C57BL/6J-related mouse strains are widely used animal models for diet-induced obesity (DIO). Multiple vendors breed C57BL/6J-related substrains which may introduce genetic drift and...
Effects of different diets used in diet-induced obesity models on ...
WEBDec 20, 2019 · We found that both CAF and HFD led reliably to obesity. The body weight in HFD and CAF mice was significantly higher than that of SCD and NFD mice, which were comparable in this regard.
The hedonic overdrive model best explains high‐fat diet‐induced obesity …
WEBFeb 27, 2024 · High-fat diets cause obesity in male mice; however, the underlying mechanisms remain controversial. Here, three contrasting ideas were assessed: hedonic overdrive, reverse causality, and passive overconsumption models. Method s.
Novel weight loss diet attenuates dietary-induced obesity in mice …
WEBNov 11, 2022 · Novel weight loss diet attenuates dietary-induced obesity in mice and might correlate with altered gut microbiota and metabolite profiles - PMC. Journal List. Front Nutr. PMC9692001. As a library, NLM provides access to scientific literature.
New research uncovers a path to lowering obesity in mice by …
WEBJan 17, 2022 · Blocking the activity of an enzyme inside fat cells can decrease obesity and related health disorders in mice, according to new research led by the University of Michigan Life Sciences Institute.
Camptothecin effectively treats obesity in mice through GDF15
WEBFeb 24, 2022 · This study reveals that the small molecule Camptothecin induces endogenous GDF15, suppressing food intake and reducing body weight in obese mice, suggesting a promising candidate for anti-obesity treatment.
Exercise-induced molecule reduces obesity in mice
WEBJul 12, 2022 · Researchers found that a molecule produced during exercise by various mammals, including people, can reduce food consumption and obesity in mice. The results further our understanding of how exercise influences body weight.
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